This is fiction but very good fiction from a very talented author
Neuroscientist and debut novelist Genova mines years of experience in her field to craft a realistic portrait of early onset Alzheimer’s disease. Alice Howland has a career not unlike Genova’s—she’s an esteemed psychology professor at Harvard, living a comfortable life in Cambridge with her husband, John, arguing about the usual (making quality time together, their daughter’s move to L.A.) when the first symptoms of Alzheimer’s begin to emerge. First, Alice can’t find her Blackberry, then she becomes hopelessly disoriented in her own town. Alice is shocked to be diagnosed with early onset Alzheimer’s (she had suspected a brain tumor or menopause), after which her life begins steadily to unravel. She loses track of rooms in her home, resigns from Harvard and eventually cannot recognize her own children.
But this is fact!
Breakthrough Replicates Human Brain Cells for Use in Alzheimer’s Research
For the first time, and to the astonishment of many of their colleagues, researchers created what they call Alzheimer’s in a Dish — a petri dish with human brain cells that develop the telltale structures of Alzheimer’s disease. In doing so, they resolved a longstanding problem of how to study Alzheimer’s and search for drugs to treat it; the best they had until now were mice that developed an imperfect form of the disease.
The key to their success, said the lead researcher, Rudolph E. Tanzi ofMassachusetts General Hospital in Boston, was a suggestion by his colleague Doo Yeon Kim to grow human brain cells in a gel, where they formed networks as in an actual brain. They gave the neurons genes for Alzheimer’s disease. Within weeks they saw the hard Brillo-like clumps known as plaques and then the twisted spaghetti-like coils known as tangles — the defining features of Alzheimer’s disease.
The work, which also offers strong support for an old idea about how the disease progresses, was published in Nature on Sunday. Leading researchers said it should have a big effect.
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